Publications

Zhou J, Vitali I, Roig-Puiggros S, Javed A, Cantando I, Puglisi M, Bezzi P, Jabaudon D, Mayer C, Bocchi R. (2025). Dual lineage origins contribute to neocortical astrocyte diversity. https://doi.org/10.1038/s41467-025-61829-4
Liu S, Faitg J, Tissot C, Konstantopoulos D, Laws R, Bourdier G, Andreux PA, Davey T, Gallart-Ayala H, Ivanisevic J, Singh A, Rinsch C, Marcinek DJ, D’Amico D. (2025). Urolithin A provides cardioprotection and mitochondrial quality enhancement preclinically and improves human cardiovascular health biomarkers. https://doi.org/10.1016/j.isci.2025.111814
Baumann N, Wagener RJ, Javed A, Conti E, Abe P, Lopes A, Sansevrino R, Lavalley A, Magrinelle, E, Szalai T, Fuciec Dm Ferreira C, Fievre S, Fouassier A, D’amico D, Harshnitz O, Jabaudon D. (2025). Regional differences in progenitor metabolism shape brain growth during development. https://doi.org/10.1016/j.cell.2025.04.003
Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives. (n.d.). https://doi.org/10.3389/fphys.2021.825816
Barra B, Conti S, Perich M, Zhuang K, Schiavone G, Fallegger F, Galan K, James N, Barraud Q, Delacombaz M, Kaeser M, Rouiller E, Milekovic T, Lacour S, Bloch J, Courtine G, Capogrosso M. (2022). Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys. https://doi.org/10.1038/s41593-022-01106-5
Pasquini M, James N, Dewany I, Coen FV, Cho N, Lai S, Anil S, Carpaneto J, Barraud Q, Lacour S, Micera S* and Courtine G. (2022). Preclinical neurorobotic platform to develop therapies for upper-limb movement recovery. https://doi.org/10.1126/scirobotics.abk2378
Shur M, Akouissi O, Rizzo O, Colin DJ, Kolinski JM, Lacour SP. (n.d.). Revealing the complexity of ultra-soft hydrogel re-swelling inside the brain. https://doi.org/10.1016/j.biomaterials.2023.122024
McInturff S, Coen FV, Hight AE, Tarabichi O, Kanumuri VV, Vachicouras N, Lacour SP, Lee DJ, Brown MC.J. (2022). Comparison of Responses to DCN vs. VCN Stimulation in a Mouse Model of the Auditory Brainstem Implant (ABI). https://doi.org/10.1007/s10162-022-00840-8
Schiavone G, Kang X, Fallegger F, Gandar J, Courtine G, Lacour SP. (2020). Guidelines to Study and Develop Soft Electrode Systems for Neural Stimulation. https://doi.org/10.1016/j.neuron.2020.10.010
Michoud F, Seehus C, Schönle P, Brun N, Taub D, Zhang Z, Jain A, Furfaro I, Akouissi O, Moon R, Meier P, Galan K, Doyle B, Tetreault M, Talbot S, Browne LE, Huang Q, Woolf CJ, Lacour SP. (2020). Epineural optogenetic activation of nociceptors initiates and amplifies inflammation. https://doi.org/10.1038/s41587-020-0673-2
Michoud F, Sottas L, Browne LE, Asboth L, Latremoliere A, Sakuma M, Courtine G, Woolf CJ, Lacour SP.J. (2018). Optical cuff for optogenetic control of the peripheral nervous system. https://doi.org/10.1088/1741-2552/aa9126
D D’Amico, AM Fouassier, J Faitg, N Hennighausen, M Brandt, D Konstantopoulos, C Rinsch, A Singh. (2023). Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials. https://doi.org/https://doi.org/10.1101/2023.06.16.23291378
A. Wilhelmsen, LG. Karagounis, AJ. Bennett, D. D’amico, AM. Fouassier, SW. Jones, K. Tsintzas. (2025). The polyphenol metabolite urolithin A suppresses myostatin expression and augments glucose uptake in human skeletal muscle cells. https://doi.org/10.1186/s12986-025-00909-0
Paggi, V., Fallegger, F., Serex, L., Rizzo, O., Galan, K., Giannotti, A., Furfaro, I., Zinno, C., Bernini, F., Micera, S., & Lacour, S. P. (2024). A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation. Bioelectronic Medicine, 10(1). https://doi.org/10.1186/s42234-023-00137-y
Müller, Y., Lengacher, L., Friscourt, F., Quairiaux, C., Stoppini, L., Magistretti, P. J., Lengacher, S., & Finsterwald, C. (2024). Epileptiform activity in brain organoids derived from patient with Glucose Transporter 1 Deficiency Syndrome. Frontiers in Neuroscience, 18. https://doi.org/10.3389/fnins.2024.1498801
Cho, N., Squair, J. W., Aureli, V., James, N. D., Bole-Feysot, L., Dewany, I., Hankov, N., Baud, L., Leonhartsberger, A., Sveistyte, K., Skinnider, M. A., Gautier, M., Laskaratos, A., Galan, K., Goubran, M., Ravier, J., Merlos, F., Batti, L., Pagès, S., … Courtine, G. (2024). Hypothalamic deep brain stimulation augments walking after spinal cord injury. Nature Medicine, 30(12), 3676–3686. https://doi.org/10.1038/s41591-024-03306-x
Sanches, E., Ho, D., Van De Looij, Y., Aebi Toulotte, A., Baud, L., Bouteldja, F., Barraud, Q., Araneda, R., Bleyenheuft, Y., Brochard, S., Kathe, C., Courtine, G., & Sizonenko, S. (2024). Early intensive rehabilitation reverses locomotor disruption, decrease brain inflammation and induces neuroplasticity following experimental Cerebral Palsy. Brain, Behavior, and Immunity, 121, 303–316. https://doi.org/10.1016/j.bbi.2024.08.005
Ho, D., Sanches, E. F., & Sizonenko, S. V. (2022). Early neurodevelopmental reflex impairments in a rodent model of cerebral palsy. International Journal of Developmental Neuroscience, 82(8), 814–822. https://doi.org/10.1002/jdn.10235
D’Amico, D., Olmer, M., Fouassier, A. M., Valdés, P., Andreux, P. A., Rinsch, C., & Lotz, M. (2022). Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis. Aging Cell, 21(8), e13662. https://doi.org/10.1111/acel.13662
Singh, A., D’Amico, D., Andreux, P. A., Fouassier, A. M., Blanco-Bose, W., Evans, M., Aebischer, P., Auwerx, J., & Rinsch, C. (2022). Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine, 3(5), 100633. https://doi.org/10.1016/j.xcrm.2022.100633
Liu, S., Faitg, J., Tissot, C., Konstantopoulos, D., Laws, R., Bourdier, G., Andreux, P. A., Davey, T., Singh, A., Rinsch, C., Marcinek, D. J., & D’Amico, D. (2023). Urolithin A induces cardioprotection and enhanced mitochondrial quality during natural aging and heart failure. https://doi.org/10.1101/2023.08.22.554375
Finsterwald, C., Dias, S., Magistretti, P. J., & Lengacher, S. (2021). Ganglioside GM1 Targets Astrocytes to Stimulate Cerebral Energy Metabolism. Frontiers in Pharmacology, 12, 653842. https://doi.org/10.3389/fphar.2021.653842
Sipion, M., Ferreira, F. M., Scholler, J., Brana, C., Gora, M., Kouvas, G., Barthet, G., & Sobolewski, A. (2023). A randomized, blinded study of photobiomodulation in a mouse model of Alzheimer’s disease showed no preventive effect. Scientific Reports, 13(1), 19828. https://doi.org/10.1038/s41598-023-47039-2
Ye, S., Lauer, J., Zhou, M., Mathis, A., & Mathis, M. W. (2023). AmadeusGPT: a natural language interface for interactive animal behavioral analysis. https://doi.org/10.48550/ARXIV.2307.04858
Ye, S., Filippova, A., Lauer, J., Schneider, S., Vidal, M., Qiu, T., Mathis, A., & Mathis, M. W. (2024). SuperAnimal pretrained pose estimation models for behavioral analysis. Nature Communications, 15(1), 5165. https://doi.org/10.1038/s41467-024-48792-2
Achard, C., Kousi, T., Frey, M., Vidal, M., Paychère, Y., Hofmann, C., Iqbal, A., Hausmann, S. B., Pagès, S., & Mathis, M. W. (2024). CellSeg3D: self-supervised 3D cell segmentation for microscopy. https://doi.org/10.1101/2024.05.17.594691
Vachicouras, N., Tarabichi, O., Kanumuri, V. V., Tringides, C. M., Macron, J., Fallegger, F., Thenaisie, Y., Epprecht, L., McInturff, S., Qureshi, A. A., Paggi, V., Kuklinski, M. W., Brown, M. C., Lee, D. J., & Lacour, S. P. (2019). Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants. Science Translational Medicine, 11(514), eaax9487. https://doi.org/10.1126/scitranslmed.aax9487
Shur, M., Fallegger, F., Pirondini, E., Roux, A., Bichat, A., Barraud, Q., Courtine, G., & Lacour, S. P. (2020). Soft Printable Electrode Coating for Neural Interfaces. ACS Applied Bio Materials, 3(7), 4388–4397. https://doi.org/10.1021/acsabm.0c00401
Von Zitzewitz, J., Asboth, L., Fumeaux, N., Hasse, A., Baud, L., Vallery, H., & Courtine, G. (2016). A neurorobotic platform for locomotor prosthetic development in rats and mice. Journal of Neural Engineering, 13(2), 026007. https://doi.org/10.1088/1741-2560/13/2/026007
Wurth, S., Capogrosso, M., Raspopovic, S., Gandar, J., Federici, G., Kinany, N., Cutrone, A., Piersigilli, A., Pavlova, N., Guiet, R., Taverni, G., Rigosa, J., Shkorbatova, P., Navarro, X., Barraud, Q., Courtine, G., & Micera, S. (2017). Long-term usability and bio-integration of polyimide-based intra-neural stimulating electrodes. Biomaterials, 122, 114–129. https://doi.org/10.1016/j.biomaterials.2017.01.014
Asboth, L., Friedli, L., Beauparlant, J., Martinez-Gonzalez, C., Anil, S., Rey, E., Baud, L., Pidpruzhnykova, G., Anderson, M. A., Shkorbatova, P., Batti, L., Pagès, S., Kreider, J., Schneider, B. L., Barraud, Q., & Courtine, G. (2018). Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion. Nature Neuroscience, 21(4), 576–588. https://doi.org/10.1038/s41593-018-0093-5
Bonizzato, M., Pidpruzhnykova, G., DiGiovanna, J., Shkorbatova, P., Pavlova, N., Micera, S., & Courtine, G. (2018). Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury. Nature Communications, 9(1), 3015. https://doi.org/10.1038/s41467-018-05282-6
Hutson, T. H., Kathe, C., Palmisano, I., Bartholdi, K., Hervera, A., De Virgiliis, F., McLachlan, E., Zhou, L., Kong, G., Barraud, Q., Danzi, M. C., Medrano-Fernandez, A., Lopez-Atalaya, J. P., Boutillier, A. L., Sinha, S. H., Singh, A. K., Chaturbedy, P., Moon, L. D. F., Kundu, T. K., … Di Giovanni, S. (2019). Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models. Science Translational Medicine, 11(487), eaaw2064. https://doi.org/10.1126/scitranslmed.aaw2064
Bourrier, A., Shkorbatova, P., Bonizzato, M., Rey, E., Barraud, Q., Courtine, G., Othmen, R., Reita, V., Bouchiat, V., & Delacour, C. (2019). Monolayer Graphene Coating of Intracortical Probes for Long‐Lasting Neural Activity Monitoring. Advanced Healthcare Materials, 8(18), 1801331. https://doi.org/10.1002/adhm.201801331
Skinnider, M. A., Squair, J. W., Kathe, C., Anderson, M. A., Gautier, M., Matson, K. J. E., Milano, M., Hutson, T. H., Barraud, Q., Phillips, A. A., Foster, L. J., La Manno, G., Levine, A. J., & Courtine, G. (2021). Cell type prioritization in single-cell data. Nature Biotechnology, 39(1), 30–34. https://doi.org/10.1038/s41587-020-0605-1
Squair, J. W., Gautier, M., Mahe, L., Soriano, J. E., Rowald, A., Bichat, A., Cho, N., Anderson, M. A., James, N. D., Gandar, J., Incognito, A. V., Schiavone, G., Sarafis, Z. K., Laskaratos, A., Bartholdi, K., Demesmaeker, R., Komi, S., Moerman, C., Vaseghi, B., … Phillips, A. A. (2021). Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury. Nature, 590(7845), 308–314. https://doi.org/10.1038/s41586-020-03180-w
Bonizzato, M., James, N. D., Pidpruzhnykova, G., Pavlova, N., Shkorbatova, P., Baud, L., Martinez-Gonzalez, C., Squair, J. W., DiGiovanna, J., Barraud, Q., Micera, S., & Courtine, G. (2021). Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury. Nature Communications, 12(1), 1925. https://doi.org/10.1038/s41467-021-22137-9
Kathe, C., Michoud, F., Schönle, P., Rowald, A., Brun, N., Ravier, J., Furfaro, I., Paggi, V., Kim, K., Soloukey, S., Asboth, L., Hutson, T. H., Jelescu, I., Philippides, A., Alwahab, N., Gandar, J., Huber, D., De Zeeuw, C. I., Barraud, Q., … Courtine, G. (2022). Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice. Nature Biotechnology, 40(2), 198–208. https://doi.org/10.1038/s41587-021-01019-x
Squair, J. W., Gautier, M., Kathe, C., Anderson, M. A., James, N. D., Hutson, T. H., Hudelle, R., Qaiser, T., Matson, K. J. E., Barraud, Q., Levine, A. J., La Manno, G., Skinnider, M. A., & Courtine, G. (2021). Confronting false discoveries in single-cell differential expression. Nature Communications, 12(1), 5692. https://doi.org/10.1038/s41467-021-25960-2
Badi, M., Wurth, S., Scarpato, I., Roussinova, E., Losanno, E., Bogaard, A., Delacombaz, M., Borgognon, S., C̆vanc̆ara, P., Fallegger, F., Su, D. K., Schmidlin, E., Courtine, G., Bloch, J., Lacour, S. P., Stieglitz, T., Rouiller, E. M., Capogrosso, M., & Micera, S. (2021). Intrafascicular peripheral nerve stimulation produces fine functional hand movements in primates. Science Translational Medicine, 13(617), eabg6463. https://doi.org/10.1126/scitranslmed.abg6463
Barra, B., Conti, S., Perich, M. G., Zhuang, K., Schiavone, G., Fallegger, F., Galan, K., James, N. D., Barraud, Q., Delacombaz, M., Kaeser, M., Rouiller, E. M., Milekovic, T., Lacour, S., Bloch, J., Courtine, G., & Capogrosso, M. (2022). Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys. Nature Neuroscience, 25(7), 924–934. https://doi.org/10.1038/s41593-022-01106-5
Pasquini, M., James, N. D., Dewany, I., Coen, F.-V., Cho, N., Lai, S., Anil, S., Carpaneto, J., Barraud, Q., Lacour, S. P., Micera, S., & Courtine, G. (2022). Preclinical upper limb neurorobotic platform to assess, rehabilitate, and develop therapies. Science Robotics, 7(64), eabk2378. https://doi.org/10.1126/scirobotics.abk2378
Kathe, C., Skinnider, M. A., Hutson, T. H., Regazzi, N., Gautier, M., Demesmaeker, R., Komi, S., Ceto, S., James, N. D., Cho, N., Baud, L., Galan, K., Matson, K. J. E., Rowald, A., Kim, K., Wang, R., Minassian, K., Prior, J. O., Asboth, L., … Courtine, G. (2022). The neurons that restore walking after paralysis. Nature, 611(7936), 540–547. https://doi.org/10.1038/s41586-022-05385-7
Soriano, J. E., Hudelle, R., Squair, J. W., Mahe, L., Amir, S., Gautier, M., Puchalt, V. P., Barraud, Q., Phillips, A. A., & Courtine, G. (2023). Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models. Nature Protocols, 18(2), 340–373. https://doi.org/10.1038/s41596-022-00764-w
Lorach, H., Galvez, A., Spagnolo, V., Martel, F., Karakas, S., Intering, N., Vat, M., Faivre, O., Harte, C., Komi, S., Ravier, J., Collin, T., Coquoz, L., Sakr, I., Baaklini, E., Hernandez-Charpak, S. D., Dumont, G., Buschman, R., Buse, N., … Courtine, G. (2023). Walking naturally after spinal cord injury using a brain–spine interface. Nature, 618(7963), 126–133. https://doi.org/10.1038/s41586-023-06094-5
Squair, J. W., Milano, M., De Coucy, A., Gautier, M., Skinnider, M. A., James, N. D., Cho, N., Lasne, A., Kathe, C., Hutson, T. H., Ceto, S., Baud, L., Galan, K., Aureli, V., Laskaratos, A., Barraud, Q., Deming, T. J., Kohman, R. E., Schneider, B. L., … Anderson, M. A. (2023). Recovery of walking after paralysis by regenerating characterized neurons to their natural target region. Science, 381(6664), 1338–1345. https://doi.org/10.1126/science.adi6412
Moritz, C., Field-Fote, E. C., Tefertiller, C., Van Nes, I., Trumbower, R., Kalsi-Ryan, S., Purcell, M., Janssen, T. W. J., Krassioukov, A., Morse, L. R., Zhao, K. D., Guest, J., Marino, R. J., Murray, L. M., Wecht, J. M., Rieger, M., Pradarelli, J., Turner, A., D’Amico, J., … Courtine, G. (2024). Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial. Nature Medicine, 30(5), 1276–1283. https://doi.org/10.1038/s41591-024-02940-9
Skinnider, M. A., Gautier, M., Teo, A. Y. Y., Kathe, C., Hutson, T. H., Laskaratos, A., De Coucy, A., Regazzi, N., Aureli, V., James, N. D., Schneider, B., Sofroniew, M. V., Barraud, Q., Bloch, J., Anderson, M. A., Squair, J. W., & Courtine, G. (2024). Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica. Nature, 631(8019), 150–163. https://doi.org/10.1038/s41586-024-07504-y